A rigid mind limits cognition. In neurological disorders, our ability to move, remember, empathize, learn, or recover from trauma is not limited by will but by the capacity of our neurons to generate components for mental flexibility. Plasticity in the brain counters this rigidity, yet we lack insight into opening plasticity windows in the brain. Psychedelics, such as psilocybin, have been used in Indigenous healing practices for millennia to engage cognitive connection and open pathways to healing. Likewise, intensive clinical exploration of psychedelics since the mid-20th century reveals their potential for treating neuropsychiatric conditions.